A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth.

ABSTRACT:

Background

The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown.

Methodology/principal findings

Using animal models of breast cancer metastasis, we show that a population of host macrophages displaying a distinct phenotype is recruited to extravasating pulmonary metastatic cells regardless of species of origin. Ablation of this macrophage population through three independent means (genetic and chemical) showed that these macrophages are required for efficient metastatic seeding and growth. Importantly, even after metastatic growth is established, ablati

SUBMITTER: Qian B 

PROVIDER: S-EPMC2721818 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature