Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues.

ABSTRACT:

Background

More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts--NATs), some of which may play a key role in a range of human diseases. To date, several databases of in silico defined human sense-antisense (SAS) pairs have appeared, however no study has focused on differential expression of SAS pairs in breast tissue. We therefore investigated the expression levels of sense and antisense transcripts in normal and malignant human breast epithelia using the Affymetrix HG-U133 Plus 2.0 and Almac Diagnostics Breast Cancer DSA microarray technologies as well as massively parallel signature sequencing (MPSS) data.

Results

The expression of more than 2500 antisense transcripts were detected in normal breast duct luminal ce

SUBMITTER: Grigoriadis A 

PROVIDER: S-EPMC2721853 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature