Ontology highlight
ABSTRACT:
SUBMITTER: Dunning AM
PROVIDER: S-EPMC2722230 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Human molecular genetics 20090106 6
We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variants (SNPs) in more than 55,000 breast cancer cases and controls from studies within the Breast Cancer Association Consortium (BCAC). No large risks or highly significant associations were revealed. SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations. Carri ...[more]