Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia.

ABSTRACT: Cortical excitatory glutamatergic projection neurons and inhibitory GABAergic interneurons follow substantially different developmental programs. In rodents, projection neurons originate from progenitors within the dorsal forebrain, whereas interneurons arise from progenitors in the ventral forebrain. In contrast, it has been proposed that in humans, the majority of cortical interneurons arise from progenitors within the dorsal forebrain, suggesting that their origin and migration is complex and evolutionarily divergent. However, whether molecularly defined human cortical interneuron subtypes originate from distinct progenitors, including those in the ventral forebrain, remains unknown. Furthermore, abnormalities in cortical interneurons have been linked to human disorders, yet no distinct

SUBMITTER: Fertuzinhos S 

PROVIDER: S-EPMC2722430 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature