Novel transcriptional profile in wrist muscles from cerebral palsy patients.

ABSTRACT:

Background

Cerebral palsy (CP) is an upper motor neuron disease that results in a progressive movement disorder. Secondary to the neurological insult, muscles from CP patients often become spastic. Spastic muscle is characterized by an increased resistance to stretch, but often develops the further complication of contracture which represents a prominent disability in children with CP. This study's purpose is to characterize alterations of spastic muscle on the transcriptional level. Increased knowledge of spastic muscle may lead to novel therapies to improve the quality of life for children with CP.

Method

The transcriptional profile of spastic muscles were defined in children with cerebral palsy and compared to control patients using Affymetrix U133A chips. Expression data

SUBMITTER: Smith LR 

PROVIDER: S-EPMC2722667 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature