A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering.

ABSTRACT:

Background

The B cell antigen receptor (BCR) is a signaling complex that mediates the differentiation of stage-specific cell fate decisions in B lymphocytes. While several studies have shown differences in signal transduction components as being key to contrasting phenotypic outcomes, little is known about the differential BCR-triggered gene transcription downstream of the signaling cascades.

Results

Here we define the transcriptional changes that underlie BCR-induced apoptosis and proliferation of immature and mature B cells, respectively. Comparative genome-wide expression profiling identified 24 genes that discriminated between the early responses of the two cell types to BCR stimulation. Using mice with a conditional Myc-deletion, we validated the microarray data by demo

SUBMITTER: Murn J 

PROVIDER: S-EPMC2722676 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature