Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation.

ABSTRACT:

Background

The Intergenic Breakage Model, which is the current model of structural genome evolution, considers that evolutionary rearrangement breakages happen with a uniform propensity along the genome but are selected against in genes, their regulatory regions and in-between. However, a growing body of evidence shows that there exists regions along mammalian genomes that present a high susceptibility to breakage. We reconsidered this question taking advantage of a recently published methodology for the precise detection of rearrangement breakpoints based on pairwise genome comparisons.

Results

We applied this methodology between the genome of human and those of five sequenced eutherian mammals which allowed us to delineate evolutionary breakpoint regions along the human ge

SUBMITTER: Lemaitre C 

PROVIDER: S-EPMC2722678 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature