Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups.

ABSTRACT: To assess the ability of resting-state functional magnetic resonance imaging to distinguish known risk factors for AD, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the apolipoprotein e4 allele compared to 12 individuals who were not carriers of the APOE4 gene and did not have a family history of AD. Blood oxygen level dependent fMRI was performed evaluating encoding-associated signal and resting-state default mode network signal differences between the two risk groups. Neurocognitive testing revealed that the high risk group performed worse on category fluency testing, but the groups were equivalent on all other cognitive measures. During encoding of novel face-name pairs, there were no regions of encoding-associated BOLD activations t

SUBMITTER: Fleisher AS 

PROVIDER: S-EPMC2722694 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature