Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.

ABSTRACT: Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in 492 Mexican children with asthma, predominantly atopic by skin prick test, and their parents using the Illumina HumanHap 550 K BeadChip to identify novel genetic variation for childhood asthma. The 520,767 autosomal single nucleotide polymorphisms (SNPs) passing quality control were tested for association with childhood asthma using log-linear regression with a log-additive risk model. Eleven of the most significantly associated GWAS SNPs were tested for replication in an independent study of 177 Mexican case-parent trios with childhood-onset asthma and atopy using log-lin

SUBMITTER: Hancock DB 

PROVIDER: S-EPMC2722731 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature