MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines.

ABSTRACT:

Background

MicroRNAs (miRNAs) are short single stranded noncoding RNAs that suppress gene expression through either translational repression or degradation of target mRNAs. The annealing between messenger RNAs and 5' seed region of miRNAs is believed to be essential for the specific suppression of target gene expression. One miRNA can have several hundred different targets in a cell. Rapidly accumulating evidence suggests that many miRNAs are involved in cell cycle regulation and consequentially play critical roles in carcinogenesis.

Methodology/principal findings

Introduction of synthetic miR-107 or miR-185 suppressed growth of the human non-small cell lung cancer cell lines. Flow cytometry analysis revealed these miRNAs induce a G1 cell cycle arrest in H1299 cells and the

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC2722734 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature