Pushing structural information into the yeast interactome by high-throughput protein docking experiments.

ABSTRACT: The last several years have seen the consolidation of high-throughput proteomics initiatives to identify and characterize protein interactions and macromolecular complexes in model organisms. In particular, more that 10,000 high-confidence protein-protein interactions have been described between the roughly 6,000 proteins encoded in the budding yeast genome (Saccharomyces cerevisiae). However, unfortunately, high-resolution three-dimensional structures are only available for less than one hundred of these interacting pairs. Here, we expand this structural information on yeast protein interactions by running the first-ever high-throughput docking experiment with some of the best state-of-the-art methodologies, according to our benchmarks. To increase the coverage of the interaction space, w

SUBMITTER: Mosca R 

PROVIDER: S-EPMC2722787 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature