Estimation of the warfarin dose with clinical and pharmacogenetic data.

ABSTRACT:

Background

Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfarin dose that is based on both clinical and genetic data from a broad population base.

Methods

Clinical and genetic data from 4043 patients were used to create a dose algorithm that was based on clinical variables only and an algorithm in which genetic information was added to the clinical variables. In a validation cohort of 1009 subjects, we evaluated the potential clinical value of each algorithm by calculating the percentage of pa

SUBMITTER: International Warfarin Pharmacogenetics Consortium 

PROVIDER: S-EPMC2722908 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature