Ontology highlight
ABSTRACT:
SUBMITTER: Leinninger GM
PROVIDER: S-EPMC2723060 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Cell metabolism 20090801 2
The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA) and other components of the mesolimbic dopamine (DA) system to control motivation, including the incentive to feed. The anorexigenic hormone leptin modulates the mesolimbic DA system, although the mechanisms underlying this control have remained incompletely understood. We show that leptin directly regulates a population of leptin receptor (LepRb)-expressing inhibitory neurons in the LHA and that leptin act ...[more]