Rooting human parechovirus evolution in time.

ABSTRACT:

Background

The Picornaviridae family contains a number of important pathogenic viruses, among which the recently reclassified human parechoviruses (HPeVs). These viruses are widespread and can be grouped in several types. Understanding the evolutionary history of HPeV could answer questions such as how long the circulating lineages last shared a common ancestor and how the evolution of this viral species is shaped by its population dynamics. Using both strict and relaxed clock Bayesian phylogenetics we investigated 1) the substitutions rates of the structural P1 and capsid VP1 regions and 2) evolutionary timescale of currently circulating HPeV lineages.

Results

Our estimates reveal that human parechoviruses exhibit high substitution rates for both structural P1 and capsid VP

SUBMITTER: Faria NR 

PROVIDER: S-EPMC2723090 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature