Host sequence motifs shared by HIV predict response to antiretroviral therapy.

ABSTRACT:

Background

The HIV viral genome mutates at a high rate and poses a significant long term health risk even in the presence of combination antiretroviral therapy. Current methods for predicting a patient's response to therapy rely on site-directed mutagenesis experiments and in vitro resistance assays. In this bioinformatics study we treat response to antiretroviral therapy as a two-body problem: response to therapy is considered to be a function of both the host and pathogen proteomes. We set out to identify potential responders based on the presence or absence of host protein and DNA motifs on the HIV proteome.

Results

An alignment of thousands of HIV-1 sequences attested to extensive variation in nucleotide sequence but also showed conservation of eukaryotic short linear mo

SUBMITTER: Dampier W 

PROVIDER: S-EPMC2723131 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature