The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome.

ABSTRACT: DDK syndrome is the polar-lethal embryonic death that occurs at the morula-blastocyst transition when female mice of the DDK strain are mated with males from many other inbred strains (so-called alien males). Embryonic death is caused by incompatibility between a DDK oocyte factor and an alien male gene, both of which map to the Om locus on mouse chromosome 11. We compared global transcription patterns of DDK x DDK embryos (high viability) and DDK x C57BL/6 embryos (low viability) at the morula stage, approximately 24 h before any morphological manifestations of DDK syndrome are observed. Of the transcripts that are differentially more abundant in the DDK x C57BL/6 embryos, many are the products of genes induced by the "unfolded protein response." We confirmed by quantitative RT-PCR that a

SUBMITTER: Hao L 

PROVIDER: S-EPMC2723760 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature