A model system for analyzing somatic mutations in Drosophila melanogaster.

ABSTRACT: Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.

SUBMITTER: Garcia AM 

PROVIDER: S-EPMC2723853 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature