Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails.

ABSTRACT: The snail Biomphalaria glabrata (Gastropoda, Mollusca) is an important intermediate host for the human parasite Schistosoma mansoni (Digenea, Trematoda). Anti-pathogen responses of B. glabrata were studied towards a better understanding of snail immunity and host-parasite compatibility. Open reading frame ESTs (ORESTES) were sampled from different transcriptomes of M line strain B. glabrata, 12h post-challenge with Escherichia coli (Gram-negative), Micrococcus luteus (Gram-positive) bacteria or compatible S. mansoni, and controls. The resulting 3123 ORESTES represented 2129 unique sequences (373 clusters, 1756 singletons). Of these, 175 (8.1%) were putative defense factors, including lectins, antimicrobial peptides and components of various immune-effector systems. Comparison of biological

SUBMITTER: Hanelt B 

PROVIDER: S-EPMC2724063 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature