Using genome-wide measurements for computational prediction of SH2-peptide interactions.

ABSTRACT: Peptide-recognition modules (PRMs) are used throughout biology to mediate protein-protein interactions, and many PRMs are members of large protein domain families. Recent genome-wide measurements describe networks of peptide-PRM interactions. In these networks, very similar PRMs recognize distinct sets of peptides, raising the question of how peptide-recognition specificity is achieved using similar protein domains. The analysis of individual protein complex structures often gives answers that are not easily applicable to other members of the same PRM family. Bioinformatics-based approaches, one the other hand, may be difficult to interpret physically. Here we integrate structural information with a large, quantitative data set of SH2 domain-peptide interactions to study the physical origi

SUBMITTER: Wunderlich Z 

PROVIDER: S-EPMC2724268 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature