Oral carcinoma after hematopoietic stem cell transplantation--a new classification based on a literature review over 30 years.

ABSTRACT:

Background

Patients undergoing hematopoietic stem cell transplantation (HSCT) have a higher risk of developing secondary solid tumors, in particular squamous cell carcinoma, because of several risk factors, including full-body irradiation (TBI), chemotherapy, and chronic graft versus host disease (GVHD). Based on the review presented here, a classification of oral changes is suggested in order to provide a tool to detect high-risk patients.

Methods and results

The literature over the last 30 years was reviewed for development of malignoma of the oral cavity after HSCT. Overall, 64 cases were found. In 16 out of 30 cases, the tongue was the primary location, followed by the salivary gland (10 out of 30); 56.4% appeared in a latency time of 5 to 9 years after HSCT. In 76.6%, G

SUBMITTER: Kruse AL 

PROVIDER: S-EPMC2724375 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature