Estimated autism risk and older reproductive age.

ABSTRACT:

Objectives

We sought to estimate the risk for autism associated with maternal and paternal age across successive birth cohorts.

Methods

We linked birth records and autism diagnostic records from the California Department of Developmental Services for children born in California between 1992 and 2000 to calculate the risk associated with maternal and paternal age for each birth cohort as well as for the pooled data.

Results

The categorical risks associated with maternal age over 40 years ranged from a high of 1.84 (95% confidence interval [CI] = 1.37, 2.47) to a low of 1.27 (95% CI = 0.95, 1.69). The risk associated with paternal age ranged from 1.29 (95% CI = 1.03, 1.6) to 1.71 (95% CI = 1.41, 2.08).

Conclusions

Pooling data across multiple birth cohorts inflat

SUBMITTER: King MD 

PROVIDER: S-EPMC2724463 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature