YA is needed for proper nuclear organization to transition between meiosis and mitosis in Drosophila.

ABSTRACT:

Background

The Drosophila YA protein is required to initiate the embryonic cleavage divisions. After egg activation, YA enters nuclei and interacts with chromatin and the nuclear lamina. This study was designed to define more precisely the events prior to the first cleavage division that are dependent upon YA.

Results

We find that meiosis is completed normally in the absence of YA function. The first defects in embryos and eggs from mutant mothers first appear just after the completion of meiosis, and are seen as abnormal associations among the resultant haploid nuclei. These defects are associated with asynchronies in the cell cycle-dependent chromatin condensation state of the haploid nuclei. However, we find evidence of DNA replication in the absence of YA function.

Co

SUBMITTER: Sackton KL 

PROVIDER: S-EPMC2724486 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature