Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria.

ABSTRACT:

Background

Up to half a billion human clinical cases of malaria are reported each year, resulting in about 2.7 million deaths, most of which occur in sub-Saharan Africa. Due to the over-and misuse of anti-malarials, widespread resistance to all the known drugs is increasing at an alarming rate. Rational methods to select new drug target proteins and lead compounds are urgently needed. The Discovery system provides data mining functionality on extensive annotations of five malaria species together with the human and mosquito hosts, enabling the selection of new targets based on multiple protein and ligand properties.

Methods

A web-based system was developed where researchers are able to mine information on malaria proteins and predicted ligands, as well as perform comparisons

SUBMITTER: Joubert F 

PROVIDER: S-EPMC2724543 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature