Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma.

ABSTRACT:

Rationale

T-regulatory cells (Tregs) are potent immunomodulators in allergic asthma.

Objectives

We evaluated the functional effects of Tregs by adoptively transferring naturally occurring CD4(+)CD25(+) Tregs (NTregs) and CD4(+)CD25(-) inducible Tregs (iTregs) from lung and spleens of green fluorescent protein (GFP)-transgenic Balb/c mice into cockroach-sensitized and -challenged mice.

Methods

GFP-labeled NTregs and iTregs were adoptively transferred into cockroach-sensitized and -challenged mice. Airway hyperresponsiveness (AHR) to methacholine was examined using a single-chamber, whole-body plethysmograph and invasive tracheostomy.

Measurements and main results

Adoptive transfer of either NTregs or iTregs from lung or spleen reversed airway inflammation and AH

SUBMITTER: McGee HS 

PROVIDER: S-EPMC2724714 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature