Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy.

ABSTRACT:

Background

Both induction chemotherapy followed by irradiation and concurrent chemotherapy and radiotherapy have been reported as valuable alternatives to total laryngectomy in patients with advanced larynx or hypopharynx cancer. We report results of the randomized phase 3 trial 24954 from the European Organization for Research and Treatment of Cancer.

Methods

Patients with resectable advanced squamous cell carcinoma of the larynx (tumor stage T3-T4) or hypopharynx (T2-T4), with regional lymph nodes in the neck staged as N0-N2 and with no metastasis, were randomly assigned to treatment in the sequential (or control) or the alternating (or experimental) arm. In the sequential arm, patients with a 50% or more reduction in primary tumor size after two cycles of cisplatin and 5-

SUBMITTER: Lefebvre JL 

PROVIDER: S-EPMC2724854 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature