Substance use, trait measures, and subjective response to nicotine in never-smokers stratified on parental smoking history and sex.

ABSTRACT:

Introduction

Male and female never-smokers stratified on parental history of smoking were tested for possible differences in susceptibility to the hedonic effects of nicotine.

Methods

We recruited nicotine-exposed never-smokers with two never-smoking biological parents (PH-) or two ever-smoking biological parents (PH+). After completing a baseline assessment battery focusing on conditions or behaviors associated with smoking, participants were tested for subjective and hedonic effects in response to administration of three different nicotine doses (0.0, 0.5, and 1.0 mg) via nasal spray. Physiological and biochemical reactivity also was monitored.

Results

PH+ were significantly more likely to report having experienced a "buzz" upon early smoking experimentation and to

SUBMITTER: Pomerleau OF 

PROVIDER: S-EPMC2725008 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature