The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.

ABSTRACT:

Background

The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population.

Methods

We selected 84 incident gastric cancer cases and 336 matched controls nested within the Korean Multi-Center Cancer Cohort. Six SNPs on the TNF gene, TNF-alpha-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C, and TNF-beta 252 A/G were genotyped. The ORs (95% CIs) were calculated using unconditional logistic regression model to detect each SNP and haplotype-pair effects for gastric cancer. The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. Multi dimensionality reduction (MDR) analyses were performed to explore the

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC2725140 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature