Clinical efficacy and immune regulation with peanut oral immunotherapy.

ABSTRACT:

Background

Oral immunotherapy (OIT) has been thought to induce clinical desensitization to allergenic foods, but trials coupling the clinical response and immunologic effects of peanut OIT have not been reported.

Objective

The study objective was to investigate the clinical efficacy and immunologic changes associated with OIT.

Methods

Children with peanut allergy underwent an OIT protocol including initial day escalation, buildup, and maintenance phases, and then oral food challenge. Clinical response and immunologic changes were evaluated.

Results

Of 29 subjects who completed the protocol, 27 ingested 3.9 g peanut protein during food challenge. Most symptoms noted during OIT resolved spontaneously or with antihistamines. By 6 months, titrated skin prick tests

SUBMITTER: Jones SM 

PROVIDER: S-EPMC2725434 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature