Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal reflux.

ABSTRACT:

Background & aims

An association between female hormones and symptomatic gastroesophageal reflux disease (GERD) and may be modified by obesity is suggested but not proven. Factors affecting GERD progression, however, are largely unknown.

Methods

At 40 US clinical centers, postmenopausal women with hysterectomy (n = 10,739) were randomly assigned to receive 0.625 mg/d of conjugated equine estrogens or placebo. Women without hysterectomy (n = 16,608) were randomly assigned to receive estrogen plus progestin, given as 0.625 mg conjugated equine estrogens/d plus 2.5 mg medroxyprogesterone acetate/d, or placebo. We performed secondary analyses using data from these trials.

Results

After 1 year, there was a trend toward a higher incidence of symptomatic GER among women rand

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC2725519 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature