Overexpression of VpsS, a hybrid sensor kinase, enhances biofilm formation in Vibrio cholerae.

ABSTRACT: Vibrio cholerae causes the disease cholera and inhabits aquatic environments. One key factor in the environmental survival of V. cholerae is its ability to form matrix-enclosed, surface-associated microbial communities known as biofilms. Mature biofilms rely on Vibrio polysaccharide to connect cells to each other and to a surface. We previously described a core regulatory network, which consists of two positive transcriptional regulators, VpsR and VpsT, and a negative transcriptional regulator HapR, that controls biofilm formation by regulating the expression of vps genes. In this study, we report the identification of a sensor histidine kinase, VpsS, which can control biofilm formation and activates the expression of vps genes. VpsS required the response regulator VpsR to activate vps exp

SUBMITTER: Shikuma NJ 

PROVIDER: S-EPMC2725581 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature