Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer.

ABSTRACT: A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is commonly lost in ovarian cancer, and the loss of its expression is closely associated with neoplastic transformation of the ovarian surface epithelium. In the present study, we found that reduction of GATA6 expression with small interfering RNA (siRNA) in human ovarian surface epithelial cells resulted in deformation of the nuclear envelope, failure of cytokinesis, and formation of polyploid and aneuploid cells. We further discovered that loss of the nuclear envelope protein emerin may mediate the consequences of GATA6 suppressio

SUBMITTER: Capo-chichi CD 

PROVIDER: S-EPMC2725711 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature