A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.

ABSTRACT: Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable exception to this is macrophage migration inhibitory factor (MIF). MIF, an autocrine- and paracrine-acting cytokine/growth factor, plays a pivotal role in both the initiation and maintenance of neoplastic diseases. MIF possesses a nonphysiologic enzymatic activity that is evolutionarily well-conserved. Although small molecule antagonists of MIFs enzymatic active site have been reported to inhibit biological activities of MIF, universally high IC(50)s have limited their clinical appeal. Using a computational virtual screening strategy, we have ide

SUBMITTER: Winner M 

PROVIDER: S-EPMC2726006 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature