Ontology highlight
ABSTRACT:
SUBMITTER: Fiedler M
PROVIDER: S-EPMC2726290 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Molecular cell 20080501 4
Pygo and BCL9/Legless transduce the Wnt signal by promoting the transcriptional activity of beta-catenin/Armadillo in normal and malignant cells. We show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). The crystal structures of ternary complexes between PHD, HD1, and two different H3K4me peptides reveal a unique mode of histone tail recognition: efficient histone bin ...[more]