Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.

ABSTRACT: The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population characterized by the low expression of CD21. CD21(low) B cells are polyclonal, unmutated IgM(+)IgD(+) B cells but carry a highly distinct gene expression profile which differs from conventional naïve B cells. Interestingly, while clearly not representing a memory population, they do share several features with the recently defined memory-like tissue, Fc receptor-like 4 positive B cell population in the tonsils of healthy donors. CD21(low) B cells show signs of previous activation and proliferatio

SUBMITTER: Rakhmanov M 

PROVIDER: S-EPMC2726348 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature