No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.

ABSTRACT:

Aim

To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.

Methods

We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.

Results

None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.

Conclusion

Our study does not support PTEN as a colon cancer susceptibility g

SUBMITTER: Phillips LS 

PROVIDER: S-EPMC2726455 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature