IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

ABSTRACT:

Aim

To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-alpha and the interleukin (IL)-10 in childhood Crohn's disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes.

Methods

Ten variants in GR, TNF-alpha and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin.

Results

For the GR polymorphisms (R23K and N363S) and IL-10 variants in the 5'flanking region (-1082 G > A, -819 T > C and -592 A > C), no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previou

SUBMITTER: Sanchez R 

PROVIDER: S-EPMC2726456 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature