Postsynaptic expression of tetanus toxin light chain blocks synaptogenesis in Drosophila.

ABSTRACT: During the development of the nervous system embryonic neurons are incorporated into neural networks that underlie behaviour. For example, during embryogenesis in Drosophila, motor neurons in every body segment are wired into the circuitry that drives the simple peristaltic locomotion of the larva. Very little is known about the way in which the necessary central synapses are formed in such a network or how their properties are controlled. One possibility is that presynaptic and postsynaptic elements form relatively independently of each other. Alternatively, there might be an interaction between presynaptic and postsynaptic neurons that allows for adjustment and plasticity in the embryonic network. Here we have addressed this issue by analysing the role of synaptic transmission in the for

SUBMITTER: Baines RA 

PROVIDER: S-EPMC2726806 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature