Butyrate-induced transcriptional changes in human colonic mucosa.

ABSTRACT:

Background

Fermentation of dietary fiber in the colon results in the production of short chain fatty acids (mainly propionate, butyrate and acetate). Butyrate modulates a wide range of processes, but its mechanism of action is mostly unknown. This study aimed to determine the effects of butyrate on the transcriptional regulation of human colonic mucosa in vivo.

Methodology/principal findings

Five hundred genes were found to be differentially expressed after a two week daily butyrate administration with enemas. Pathway analysis showed that the butyrate intervention mainly resulted in an increased transcriptional regulation of the pathways representing fatty acid oxidation, electron transport chain and oxidative stress. In addition, several genes associated with epithelial int

SUBMITTER: Vanhoutvin SA 

PROVIDER: S-EPMC2727000 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature