Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.

ABSTRACT: Systemic lupus erythematosus (SLE) is a complex autoimmune disease of unknown etiology that involves multiple interacting cell types driven by numerous cytokines and autoimmune epitopes. Although the initiating events leading to SLE pathology are not understood, there is a growing realization that dysregulated cytokine action on immune cells plays an important role in promoting the inflammatory autoimmune state. We applied phospho-specific flow cytometry to characterize the extent to which regulation of cytokine signal transduction through the STAT family of transcription factors is disturbed during the progression of SLE. Using a panel of 10 cytokines thought to have causal roles in the disease, we measured signaling responses at the single-cell level in five immune cell types from the MR

SUBMITTER: Hale MB 

PROVIDER: S-EPMC2727051 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature