Regional rates of neocortical atrophy from normal aging to early Alzheimer disease.

ABSTRACT:

Objective

To evaluate the spatial pattern and regional rates of neocortical atrophy from normal aging to early Alzheimer disease (AD).

Methods

Longitudinal MRI data were analyzed using high-throughput image analysis procedures for 472 individuals diagnosed as normal, mild cognitive impairment (MCI), or AD. Participants were divided into 4 groups based on Clinical Dementia Rating Sum of Boxes score (CDR-SB). Annual atrophy rates were derived by calculating percent cortical volume loss between baseline and 12-month scans. Repeated-measures analyses of covariance were used to evaluate group differences in atrophy rates across regions as a function of impairment. Planned comparisons were used to evaluate the change in atrophy rates across levels of disease severity.

Results</

SUBMITTER: McDonald CR 

PROVIDER: S-EPMC2727145 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature