Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila.

ABSTRACT: Patterns of polymorphism and divergence in Drosophila protein-coding genes suggest that a considerable fraction of amino acid differences between species can be attributed to positive selection and that genes with sex-biased expression, that is, those expressed predominantly in one sex, have especially high rates of adaptive evolution. Previous studies, however, have been restricted to autosomal sex-biased genes and, thus, do not provide a complete picture of the evolutionary forces acting on sex-biased genes across the genome. To determine the effects of X-linkage on sex-biased gene evolution, we surveyed DNA sequence polymorphism and divergence in 45 X-linked genes, including 17 with male-biased expression, 13 with female-biased expression, and 15 with equal expression in the 2 sexes. Us

SUBMITTER: Baines JF 

PROVIDER: S-EPMC2727381 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature