Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.

ABSTRACT:

Background

The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is critical for designing therapeutic modalities for reducing the occurrence of metastasis. Although ubiquitously present in most human organs, large-conductance calcium- and voltage-activated potassium channel (BKCa) channels are significantly upregulated in breast cancer cells. In this study we investigated the role of KCNMA1 gene that encodes for the pore-forming alpha-subunit of BKCa channels in breast cancer metastasis and invasion.

Methods

We performed Global exon array to study the expression of KCNMA1 in metastatic breast cancer to brain, compared its expression in primary breast cancer and breast canc

SUBMITTER: Khaitan D 

PROVIDER: S-EPMC2727533 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature