Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity.

ABSTRACT: The intrinsic properties of neurons that enable them to maintain depolarized, persistently activated states in the absence of sustained input are poorly understood. In short-term memory tasks, individual prefrontal cortical (PFC) neurons can maintain persistent action potential output during delay periods between informative cues and behavioral responses. Dopamine and drugs of abuse alter PFC function and working memory, possibly by modulating intrinsic neuronal properties. Here we used patch-clamp recording of layer 5 PFC pyramidal neurons to identify a postsynaptic depolarization that was evoked by action potential bursts and mediated by metabotropic glutamate receptor 5 (mGluR5). This depolarization occurred in the absence of recurrent synaptic activity and was reduced by a dopamine D1

SUBMITTER: Sidiropoulou K 

PROVIDER: S-EPMC2727588 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature