Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.

ABSTRACT: Cortical columns generate separate streams of information that are distributed to numerous cortical and subcortical brain regions. We asked whether local intracortical circuits reflect these different processing streams by testing whether the intracortical connectivity among pyramidal neurons reflects their long-range axonal targets. We recorded simultaneously from up to four retrogradely labelled pyramidal neurons that projected to the superior colliculus, the contralateral striatum or the contralateral cortex to assess their synaptic connectivity. Here we show that the probability of synaptic connection depends on the functional identities of both the presynaptic and postsynaptic neurons. We first found that the frequency of monosynaptic connections among corticostriatal pyramidal neuron

SUBMITTER: Brown SP 

PROVIDER: S-EPMC2727746 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature