Dendritic branching of olfactory bulb mitral and tufted cells: regulation by TrkB.

ABSTRACT:

Background

Projection neurons of mammalian olfactory bulb (OB), mitral and tufted cells, have dendrites whose morphologies are specifically differentiated for efficient odor information processing. The apical dendrite extends radially and arborizes in single glomerulus where it receives primary input from olfactory sensory neurons that express the same odor receptor. The lateral dendrites extend horizontally in the external plexiform layer and make reciprocal dendrodendritic synapses with granule cells, which moderate mitral/tufted cell activity. The molecular mechanisms regulating dendritic development of mitral/tufted cells is one of the unsolved important problems in the olfactory system. Here, we focused on TrkB receptors to test the hypothesis that neurotrophin-mediate mechani

SUBMITTER: Imamura F 

PROVIDER: S-EPMC2727791 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature