Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush.

ABSTRACT:

Background

Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains of mice.

Results

We found that RGCs are more susceptible to death following optic nerve crush in C57BL/6J mice (54% survival) than in DBA/2J mice (62% survival). Using the Illumina Mouse-6 microarray, we identified 1,580 genes with significant change in expression following optic nerve crush in these two strains of mice. Our analysis of the changes occurring after optic nerve crush demonstrated

SUBMITTER: Templeton JP 

PROVIDER: S-EPMC2727955 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature