A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.

ABSTRACT: The analysis of patient blood transcriptional profiles offers a means to investigate the immunological mechanisms relevant to human diseases on a genome-wide scale. In addition, such studies provide a basis for the discovery of clinically relevant biomarker signatures. We designed a strategy for microarray analysis that is based on the identification of transcriptional modules formed by genes coordinately expressed in multiple disease data sets. Mapping changes in gene expression at the module level generated disease-specific transcriptional fingerprints that provide a stable framework for the visualization and functional interpretation of microarray data. These transcriptional modules were used as a basis for the selection of biomarkers and the development of a multivariate transcriptiona

SUBMITTER: Chaussabel D 

PROVIDER: S-EPMC2727981 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature