Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus.

ABSTRACT:

Background

The stress-related neuropeptide corticotropin-releasing factor (CRF) is involved in determining behavioral strategies for responding to stressors, in part through its regulation of the dorsal raphe (DR)-serotonin (5-HT) system. CRF(1) and CRF(2) receptor subtypes have opposing effects on this system that are associated with active versus passive coping strategies, respectively.

Methods

Immunoelectron microscopy and in vivo single-unit recordings were used to assess CRF receptor distribution and neuronal responses, respectively, in the DR of stressed and unstressed rats.

Results

Here we show that in unstressed rats CRF(1) and CRF(2) are differentially distributed within DR cells, with CRF(1) being prominent on the plasma membrane and CRF(2) being cytoplasmic

SUBMITTER: Waselus M 

PROVIDER: S-EPMC2728006 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature