Ontology highlight
ABSTRACT:
SUBMITTER: Lee JS
PROVIDER: S-EPMC2728206 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Lee Jae-Seung JS Green Jordan J JJ Love Kevin T KT Sunshine Joel J Langer Robert R Anderson Daniel G DG
Nano letters 20090601 6
The safe and effective delivery of RNA therapeutics remains the major barrier to their broad clinical application. Here we develop a new nanoparticulate delivery system based on inorganic particles and biodegradable polycations. First, gold nanoparticles were modified with the hydrophilic polymer poly(ethylene glycol) (PEG), and then small interfering RNA (siRNA) was conjugated to the nanoparticles via biodegradable disulfide linkages, with approximately 30 strands of siRNA per nanoparticle. The ...[more]