Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.

ABSTRACT: An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics. Genome-wide transcriptional profiling of the brain tissue during experimental cerebral malaria (ECM ) caused by Plasmodium berghei ANKA parasites in mice, a well established surrogate of human cerebral malaria, has been useful in predicting the functional classes of genes involved and pathways altered during the course of disease. To further understand the contribution of individual genes to the pathogenesis of ECM, we examined the biological relevance of three molecules -- CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM. We find that CD14 plays a predomin

SUBMITTER: Oakley MS 

PROVIDER: S-EPMC2728507 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature